Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520604 | 0.81 | TAAR1 (0.39) | — | |
| SCHEMBL1616732 | 0.81 | KDM1A (0.38) | — | |
| SCHEMBL240623 | 0.81 | ADCY5 (0.38) | — | |
| SCHEMBL595524 | 0.81 | HTR3A (0.50) | HTR3A | |
| SCHEMBL571789 | 0.81 | SLC18A3 (0.41) | — | |
| SCHEMBL878092 | 0.79 | RECQL (0.34) | DDB1CRBNCHRNB2CHRNA4 | |
| SCHEMBL9363501 | 0.77 | HTR2C (0.49) | — | |
| SCHEMBL9331689 | 0.77 | MAOA (0.50) | HTR3A | |
| SCHEMBL10517231 | 0.77 | NISCH (0.39) | — | |
| SCHEMBL10517550 | 0.75 | NISCH (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433149-B1 | Serotonin antagonists, their preparation and pharmaceuticals containing them | RHONE POULENC SANTE (FR) | 1994-02-16 | — | — | EP | claimed |
| EP-0350403-B1 | (AZA)NAPHTHALENESULTAM DERIVATIVES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAME | RHONE-POULENC SANTE (FR) | 1993-01-13 | — | — | EP | claimed |
| JP-3255063-A | — | — | None | — | — | JP | disclosed |
| US-5130313-A | Central nervous system disorders, cardiovascular disorders or gastrointestinal disorders | RHONE-POULENC SANTE (FR) | 1992-07-14 | — | — | US | disclosed |
| JP-H03255063-A | SEROTONIN ANTAGONIST, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | RHONE POULENC SANTE | 1991-11-13 | — | — | JP | disclosed |
| US-5036075-A | Serotonin antagonists | RHONE-POULENC SANTE (FR) | 1991-07-30 | — | — | US | disclosed |
| US-5021420-A | Antiserotonine agents; central nervous system, gastroin-testinal and cardiovascular disorders | RHONE-POULENC SANTE (FR) | 1991-06-04 | — | — | US | disclosed |