Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.62 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.50 |
| ▸ | ALDH1A3 | P47895 | 6/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379662 | 0.87 | SCN5A (0.59) | SCN5ADNMT1ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL22044433 | 0.84 | MEN1 (0.51) | SCN5ADNMT1ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL11491065 | 0.81 | SCN5A (0.66) | SCN5ADNMT1ALDH1A3MAPK14NPC1 | |
| SCHEMBL2016682 | 0.78 | GRM5 (0.46) | SCN5ATLR8ALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL19781793 | 0.77 | SCN5A (0.61) | SCN5ADNMT1ALDH1A3MAPK14TGFBR1 | |
| SCHEMBL936850 | 0.77 | SCN5A (1.00) | SCN5ADNMT1ALDH1A1MAPK14NPSR1 | |
| SCHEMBL11476887 | 0.75 | SCN5A (0.58) | SCN5ADNMT1ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL11486274 | 0.75 | SCN5A (0.58) | SCN5ADNMT1ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL11384331 | 0.75 | MAPK14 (0.64) | SCN5ADNMT1ALDH1A3ALDH1A1ALDH1A2 | |
| SCHEMBL11474506 | 0.75 | SCN5A (0.58) | SCN5ADNMT1ALDH1A3ALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952034-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-8754103-B2 | — | — | 2014-06-17 | — | — | US | disclosed |
| US-20110021521-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021521-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNJ2, KCNH2, KCNA3 | SCN5A 52/4885DNMT1 4222/4885ALDH1A3 2321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.