Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | PRCP | P42785 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9374939 | 0.81 | OPRM1 (0.43) | SIGMAR1 | |
| SCHEMBL9374898 | 0.80 | SIGMAR1 (0.48) | SIGMAR1 | |
| SCHEMBL9375592 | 0.77 | SIGMAR1 (0.41) | SIGMAR1ADRA2A | |
| Hydrochloric Acid SCHEMBL9376392 | 0.77 | SIGMAR1 (0.51) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9374650 | 0.75 | CHRM2 (0.49) | SIGMAR1ADRA2AESR1 | |
| SCHEMBL9374100 | 0.73 | SIGMAR1 (0.50) | SIGMAR1 | |
| SCHEMBL9379947 | 0.73 | SIGMAR1 (0.47) | SIGMAR1 | |
| SCHEMBL9378962 | 0.73 | SIGMAR1 (0.49) | SIGMAR1LMNA | |
| SCHEMBL9375377 | 0.72 | SIGMAR1 (0.43) | SIGMAR1ESR1 | |
| SCHEMBL9377826 | 0.70 | SIGMAR1 (0.43) | SIGMAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0336228-B1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-09 | — | — | EP | disclosed |
| US-5059608-A | Anticonvulsants, antiischemic agents | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-22 | — | — | US | disclosed |
| EP-0336228-A1 | Tetrahydroisoquinolines and tetrahydrobenzazepines and a process for the preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-10-11 | — | — | EP | disclosed |