Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | WDR5 | P61964 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11216126 | 0.85 | KDM4E (0.55) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20682509 | 0.83 | KDM4E (0.51) | MAPTKDM4ERAD52NPC1RAB9A | |
| SCHEMBL937021 | 0.83 | MAPT (0.66) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3922628 | 0.83 | ALDH1A1 (0.49) | MAPTKDM4ESMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL4093686 | 0.83 | SMN1; SMN2 (0.61) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1479263 | 0.82 | KDM4E (0.51) | MAPTKDM4ERAD52NPC1RAB9A | |
| SCHEMBL1481336 | 0.76 | POLB (0.58) | MAPTKDM4ERAD52RAB9ASMN1; SMN2 | |
| SCHEMBL24309781 | 0.76 | MAPT (0.62) | MAPTKDM4ERAD52NPC1RAB9A | |
| SCHEMBL29566344 | 0.76 | MAPT (0.62) | MAPTKDM4ERAD52NPC1RAB9A | |
| SCHEMBL19192738 | 0.76 | ALDH1A1 (0.58) | KDM4EALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| US-4053470-A | BACTERICIDES, ANTIBIOTICS | PARKE, DAVIS & COMPANY (US) | 1977-10-11 | — | — | US | disclosed |
| US-3954734-A | PENICILLIN AND CEPHALOSPORIN TYPE | PARKE, DAVIS & COMPANY | 1976-05-04 | — | — | US | disclosed |