Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.55 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34467400 | 0.89 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL30689191 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL1665694 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL17407220 | 0.84 | ALDH1A1 (0.58) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL2744730 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL11216126 | 0.84 | KDM4E (0.55) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL17395881 | 0.83 | NPC1 (0.68) | SMN1; SMN2MAPTLMNARAB9ANPC1 | |
| SCHEMBL6955366 | 0.83 | ALDH1A1 (0.71) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL937684 | 0.83 | MAPT (0.55) | SMN1; SMN2MAPTLMNAHTTRAB9A | |
| SCHEMBL11062391 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069288-A1 | Novel therapeutic compounds | ABBVIE INC. | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069288-A1 | Novel therapeutic compounds | MAP3K20, RPS6KB1, MAP3K1 | SMN1; SMN2 3501/4885MAPT 3755/4885KMT2A 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.