SCHEMBL9377239

SCHEMBL9377239

COc1cc(C(=O)O)ccc1Cc1cn(C(C)C)c2ccc(CCCC(=O)N(C)C)cc12

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 16/20 0.58
LTB4R Q15722 5/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9372577 0.92 PLA2G4A (0.49) PLA2G4ALTB4R
SCHEMBL9373004 0.85 CYSLTR2 (0.57) PLA2G4ALTB4R
SCHEMBL9372314 0.83
SCHEMBL9633121 0.79 PLA2G4A (0.42) PLA2G4ALTB4R
SCHEMBL9372050 0.78 CYSLTR2 (0.50) PLA2G4A
SCHEMBL9372582 0.78 PLA2G4A (0.56) PLA2G4ALTB4R
SCHEMBL9634189 0.78 PLA2G4A (0.41) PLA2G4ALTB4R
SCHEMBL9488408 0.76 PLA2G4A (0.50) PLA2G4ALTB4R
SCHEMBL9373055 0.76 PLA2G4A (0.51) PLA2G4ALTB4R
SCHEMBL9488342 0.75 PLA2G4A (0.51) PLA2G4ALTB4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0290145-B1 Aliphatic carboxamides ICI AMERICA INC (US) 1994-10-26 EP disclosed
US-4894386-A ANTIINFLAMMATORY AGENTS ICI AMERICAS INC. (US) 1990-01-16 US disclosed
EP-0290145-A1 Aliphatic carboxamides ZENECA INC. (US) 1988-11-09 EP disclosed