Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 12/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634189 | 0.98 | PLA2G4A (0.41) | PLA2G4AMTNR1AMTNR1BCYP1A2CYP2D6 | |
| SCHEMBL9633818 | 0.91 | NQO2 (0.42) | MTNR1AMTNR1BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9633707 | 0.90 | KMT2A (0.41) | MTNR1AMTNR1BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9634171 | 0.83 | PLA2G4A (0.53) | PLA2G4ALTB4RCYP2C9HIF1A | |
| SCHEMBL9633723 | 0.83 | — | — | |
| SCHEMBL9634320 | 0.82 | CYP1A2 (0.50) | MTNR1AMTNR1BCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9634990 | 0.81 | — | — | |
| SCHEMBL9634158 | 0.81 | KMT2A (0.44) | PLA2G4AMTNR1AMTNR1BKMT2A | |
| SCHEMBL9633779 | 0.81 | CYSLTR2 (0.46) | — | |
| SCHEMBL9377239 | 0.79 | PLA2G4A (0.58) | PLA2G4ALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |