Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909486 | 0.66 | ALDH1A1 (0.44) | CSNK1A1CLK2LIMK1DYRK1ACLK4 | |
| SCHEMBL9984386 | 0.65 | KDM4E (0.65) | ALDH1A1KDM4EMAPTALKSMN1; SMN2 | |
| SCHEMBL16586809 | 0.64 | KDM4E (0.63) | ALDH1A1KDM4EMAPTALKSMN1; SMN2 | |
| SCHEMBL1687647 | 0.62 | HSD17B10 (0.49) | ALDH1A1KDM4EMAPTALKADORA2A | |
| SCHEMBL824377 | 0.61 | KDM4E (0.47) | CSNK1A1CLK2LIMK1DYRK1ACLK4 | |
| SCHEMBL25635091 | 0.61 | KDM4E (0.47) | CSNK1A1CLK2LIMK1DYRK1ACLK4 | |
| SCHEMBL14815244 | 0.61 | HPGD (0.40) | ALDH1A1KDM4EPTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL23295567 | 0.60 | CSNK1A1 (1.00) | CSNK1A1CLK2LIMK1DYRK1ACLK4 | |
| SCHEMBL7983412 | 0.60 | LCK (0.48) | ALDH1A1KDM4EALKADORA2APTPN2 | |
| SCHEMBL22798921 | 0.59 | TOP2A (0.39) | ALDH1A1KDM4EMAPTALKADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281367-B1 | Substituted 1,2,4-triazolo[1,5-a]triazines as bronchodilators | RIKER LABORATORIES INC (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4734413-A | Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators | RIKER LABORATORIES, INC. (US) | 1988-03-29 | — | — | US | disclosed |