Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179757 | 0.82 | RIPK1 (0.66) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL179758 | 0.82 | RIPK1 (0.66) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL29595423 | 0.82 | RIPK1 (0.66) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL2481688 | 0.82 | RIPK1 (0.66) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL9378435 | 0.79 | RIPK1 (0.62) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL9378120 | 0.77 | RIPK1 (0.88) | RIPK1ALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9379168 | 0.77 | RIPK1 (0.63) | RIPK1ALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9383151 | 0.77 | RIPK1 (0.59) | RIPK1PIK3CDALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL12204414 | 0.76 | RIPK1 (0.62) | RIPK1ALDH1A1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9370134 | 0.76 | RIPK1 (1.00) | RIPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295695-B1 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS (JP) | 1994-06-08 | — | — | EP | claimed |
| EP-0295695-B1 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-4990529-A | Nervous system disorder | MITSUI TOATSU CHEMICALS (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4839376-A | Pyrazoline derivatives for treating cerebrovascular diseases | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0295695-A2 | Pyrazoline derivatives and agents for treating cerebrovascular diseases containing the same as active ingredient | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1988-12-21 | — | — | EP | disclosed |