SCHEMBL9378407

SCHEMBL9378407

Nc1cccc(-c2csc(NC(=O)N3CCOCS3)n2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 6/20 0.51
HDAC1 Q13547 6/20 0.51
HDAC2 Q92769 6/20 0.51
HDAC10 Q969S8 6/20 0.51
HDAC6 Q9UBN7 4/20 0.51
HDAC8 Q9BY41 3/20 0.51
HDAC4 P56524 2/20 0.51
HDAC7 Q8WUI4 2/20 0.51
HDAC11 Q96DB2 2/20 0.51
HDAC9 Q9UKV0 2/20 0.51
HDAC5 Q9UQL6 2/20 0.51
LMNA P02545 2/20 0.48
NCOR2 Q9Y618 1/20 0.48
ROCK1 Q13464 2/20 0.45
CNR2 P34972 1/20 0.44
POLB P06746 1/20 0.44
RAB9A P51151 1/20 0.43
ATM Q13315 1/20 0.43
ABL1 P00519 2/20 0.43
ROCK2 O75116 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9371131 0.88 KMT2A (0.53) LMNACNR2POLBRAB9AATM
SCHEMBL9374871 0.88 ABL1 (0.58) LMNAROCK1CNR2POLBRAB9A
SCHEMBL9375268 0.88 LMNA (0.57) LMNAROCK1CNR2POLBRAB9A
SCHEMBL9370923 0.87 LMNA (0.56) LMNACNR2RAB9AATMKMT2A
SCHEMBL9374509 0.85 LMNA (0.66) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL9370514 0.85 ALDH1A1 (0.61) LMNAPOLBRAB9AKMT2AMAPT
SCHEMBL9372690 0.85 KMT2A (0.60) HDAC3HDAC1HDAC2HDAC10HDAC6
SCHEMBL9370832 0.83 ABL1 (0.57) LMNAPOLBATMABL1KMT2A
SCHEMBL9377027 0.82 AR (0.50) LMNAROCK1CNR2RAB9AATM
SCHEMBL9371622 0.81 KMT2A (0.62) LMNAPOLBRAB9AATMABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0589985-A1 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1994-04-06 EP disclosed
WO-1993000342-A1 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-01-07 WO disclosed
EP-0519449-A1 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-12-23 EP disclosed