Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9377162 | 0.84 | CYP1A2 (0.61) | CYP1A2ACHE | |
| SCHEMBL4501798 | 0.79 | CYP1A2 (0.62) | CYP1A2ACHE | |
| SCHEMBL10846678 | 0.78 | CYP1A2 (0.70) | CYP1A2BCHECYP3A4ACHE | |
| SCHEMBL9378893 | 0.77 | CYP1A2 (0.60) | CYP1A2ACHE | |
| SCHEMBL9378899 | 0.76 | CYP1A2 (0.58) | CYP1A2ACHE | |
| SCHEMBL9381492 | 0.75 | CYP1A2 (0.57) | CYP1A2ACHE | |
| SCHEMBL9377996 | 0.70 | CYP1A2 (0.63) | CYP1A2ACHE | |
| SCHEMBL10845035 | 0.69 | ACHE (0.73) | CYP1A2BCHECYP3A4ACHEKDM4E | |
| SCHEMBL4863948 | 0.69 | APP (0.70) | CYP1A2BCHECYP3A4ACHEAPP | |
| SCHEMBL9378050 | 0.69 | CYP1A2 (0.52) | CYP1A2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368188-B1 | 1,2,3,4-Tetrahydro-1,9-acridinediamines, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-09-21 | — | — | EP | disclosed |
| EP-0368188-A1 | 1,2,3,4-Tetrahydro-1,9-acridinediamines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-05-16 | — | — | EP | disclosed |