Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DDO | Q99489 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833251 | 0.84 | KDM4E (0.55) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL3836490 | 0.82 | FLT3 (0.50) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL30073611 | 0.82 | PDGFRB (0.56) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL4265956 | 0.82 | PDGFRB (0.56) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL6586200 | 0.81 | KDM4E (0.50) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL10343383 | 0.79 | FLT3 (0.47) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL10441468 | 0.79 | PDGFRB (0.58) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL6470774 | 0.79 | FLT3 (0.47) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL31561461 | 0.79 | FLT3 (0.61) | FLT3KDM4EDAOMAPTHPGD | |
| SCHEMBL29045739 | 0.78 | FLT3 (0.46) | FLT3KDM4EDAOMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275888-B1 | Tricyclic benzimidazoles, process for their preparation and use as medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0029992-B1 | AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1983-06-29 | — | — | EP | disclosed |
| US-4378363-A | ADRENERGIC BLOCKING AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1983-03-29 | — | — | US | disclosed |