Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685600 | 0.89 | — | — | |
| SCHEMBL3642051 | 0.89 | — | — | |
| SCHEMBL1685601 | 0.89 | — | — | |
| SCHEMBL9903674 | 0.84 | ALDH1A1 (0.31) | TSHRCES2CES1 | |
| SCHEMBL9903673 | 0.84 | ALDH1A1 (0.31) | TSHRCES2CES1 | |
| SCHEMBL1685573 | 0.83 | TSHR (0.38) | TSHRCES2CES1 | |
| SCHEMBL2705446 | 0.81 | CES2 (0.40) | TSHRCES2CES1 | |
| SCHEMBL19016268 | 0.81 | — | — | |
| SCHEMBL21413022 | 0.79 | TSHR (0.42) | TSHRCES2CES1 | |
| SCHEMBL21413039 | 0.79 | TSHR (0.42) | TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426826-B1 | SUBSTITUTED ISOXAZOLIDINES AND ISOXAZOLINES | PHARMACIA AB (SE) | 1994-04-27 | — | — | EP | disclosed |
| US-5212305-A | Cyclization and forming a carbon-nitrogen bond | KABI PHARMACIA AKTIBOLAG (SE) | 1993-05-18 | — | — | US | disclosed |
| US-5155220-A | Simplified production of plaque inhibitor | KABI PHARMACIA AKTIEBOLAG (SE) | 1992-10-13 | — | — | US | disclosed |
| EP-0426826-A1 | SUBSTITUTED ISOXAZOLIDINES AND ISOXAZOLINES. | PHARMACIA AB (SE) | 1991-05-15 | — | — | EP | disclosed |
| WO-1990014342-A1 | SUBSTITUTED ISOXAZOLIDINES AND ISOXAZOLINES | PHARMACIA AB (SE) | 1990-11-29 | — | — | WO | disclosed |