Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379807 | 1.00 | ALOX5 (0.61) | ALOX5KDM1AMAOAMAOBKCNH2 | |
| SCHEMBL9380392 | 0.85 | ALOX5 (0.80) | ALOX5KDM1AKCNH2PARP10 | |
| SCHEMBL9380387 | 0.85 | ALOX5 (0.80) | ALOX5KDM1AKCNH2PARP10 | |
| SCHEMBL7959760 | 0.83 | ALOX5 (0.73) | ALOX5KDM1A | |
| SCHEMBL9383867 | 0.83 | ALOX5 (0.73) | ALOX5KDM1A | |
| SCHEMBL9381959 | 0.83 | ALOX5 (0.73) | ALOX5KDM1A | |
| SCHEMBL7959761 | 0.83 | ALOX5 (0.73) | ALOX5KDM1A | |
| SCHEMBL9381059 | 0.81 | ALOX5 (0.61) | ALOX5KCNH2 | |
| SCHEMBL9381063 | 0.81 | ALOX5 (0.61) | ALOX5KCNH2 | |
| SCHEMBL9382010 | 0.77 | ALOX5 (0.60) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |