Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Proxazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proxazole SCHEMBL8935625 | 0.79 | CYP1A2 (0.68) | TDP1CYP1A2CYP2D6HIF1AKDM4E | |
| Proxazole SCHEMBL41604 | 0.79 | CYP1A2 (0.68) | TDP1CYP1A2CYP2D6HIF1AKDM4E | |
| Proxazole SCHEMBL21827680 | 0.74 | CYP1A2 (0.59) | TDP1CYP1A2CYP2D6HIF1AKDM4E | |
| SCHEMBL14906 | 0.71 | TDP1 (1.00) | TDP1CYP1A2HIF1AKDM4EMAPT | |
| SCHEMBL29413979 | 0.71 | TDP1 (1.00) | TDP1CYP1A2HIF1AKDM4EMAPT | |
| Hydrogen Sulfide SCHEMBL28307249 | 0.70 | TDP1 (0.98) | TDP1CYP1A2HIF1AKDM4EMAPT | |
| Formic Acid SCHEMBL15401615 | 0.68 | TDP1 (0.91) | TDP1CYP1A2HIF1AKDM4EMAPT | |
| Proxazole SCHEMBL28279739 | 0.68 | HTR1A (0.59) | TDP1CYP1A2CYP2D6HIF1AKDM4E | |
| SCHEMBL27385077 | 0.66 | TDP1 (0.72) | TDP1MAPTMEN1LMNAKMT2A | |
| Valine SCHEMBL9355415 | 0.66 | TDP1 (0.82) | TDP1MAPTMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391920-B1 | Method of fabricating an active matrix, and associated mask | THALES SA (FR) | 2013-08-21 | — | — | EP | disclosed |
| WO-2011009802-A1 | TRANSPARENT OPTICAL COMPONENT WITH MICROPITS | THALES (FR) | 2011-01-27 | — | — | WO | disclosed |
| EP-1391920-A2 | Method of fabricating an active matrix, optoelectronic visualisation devices and mask for such devices | Thales (FR) | 2004-02-25 | — | — | EP | disclosed |
| WO-1995035401-A1 | HARNESS LOOM WEAVING METHOD FOR PRODUCING SUFFICIENTLY ACCURATE BLOCK, LINE OR CONTOUR PATTERNS ON A TAFFETA BASE | KOUDINOFF DIDIER (FR) | 1995-12-28 | — | — | WO | disclosed |