Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382761 | 0.91 | KDM4E (0.43) | ALDH1A1KDM4EHPGDHSD17B10ADRA2A | |
| SCHEMBL10473799 | 0.88 | PTGDR2 (0.38) | ALDH1A1KDM4EHPGDHSD17B10KLK7 | |
| SCHEMBL9378654 | 0.86 | ADORA1 (0.42) | ALDH1A1KDM4EADRA2AADRA2BADRA2C | |
| SCHEMBL9382500 | 0.85 | ADRA2A (0.59) | ALDH1A1KDM4EHPGDHSD17B10ADRA2A | |
| SCHEMBL10465449 | 0.85 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9379686 | 0.85 | KDM4E (0.39) | ALDH1A1KDM4EHPGDHSD17B10ADRA2A | |
| SCHEMBL9378909 | 0.84 | ADRA2A (0.41) | ALDH1A1KDM4EHPGDHSD17B10ADRA2A | |
| SCHEMBL8927560 | 0.83 | ADRA2A (0.43) | ALDH1A1KDM4EHPGDHSD17B10ADRA2A | |
| SCHEMBL9379679 | 0.83 | ADRA2A (0.40) | ALDH1A1KDM4EHSD17B10ADRA2AADRA2B | |
| SCHEMBL10473798 | 0.83 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344982-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-11-23 | — | — | EP | disclosed |
| US-4978660-A | 2-SUBSTITUTED-3,4,5,6-TETRAHYDROFURO(4,3,2-EF)(3)BENZAZEPINE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| WO-1989012051-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |
| EP-0344982-A2 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |