Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382761 | 0.93 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL10473799 | 0.88 | PTGDR2 (0.38) | KDM4EALDH1A1ADRA2AADRA2BADRA2C | |
| SCHEMBL9379684 | 0.87 | ADORA1 (0.38) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL9378654 | 0.86 | ADORA1 (0.42) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL9379679 | 0.86 | ADRA2A (0.40) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL9380249 | 0.85 | ALDH1A1 (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNAADRA2A | |
| SCHEMBL8926441 | 0.81 | ADRA2A (0.56) | KDM4ESMN1; SMN2ALDH1A1NPSR1RAB9A | |
| SCHEMBL9379761 | 0.81 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| SCHEMBL9385361 | 0.81 | PTGDR2 (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNANPSR1 | |
| Hydrochloric Acid SCHEMBL9380937 | 0.81 | ADRA2A (0.55) | KDM4ESMN1; SMN2ALDH1A1RAB9AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344982-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-11-23 | — | — | EP | disclosed |
| US-4978660-A | 2-SUBSTITUTED-3,4,5,6-TETRAHYDROFURO(4,3,2-EF)(3)BENZAZEPINE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| WO-1989012051-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |
| EP-0344982-A2 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |