Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Succinimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGAV | P06756 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinimide SCHEMBL6717091 | 0.94 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL6036901 | 0.94 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL434236 | 0.94 | CRBN (0.73) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL7263756 | 0.87 | — | — | |
| Succinimide SCHEMBL28744286 | 0.87 | CRBN (0.85) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL30109359 | 0.85 | CRBN (0.69) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL9729105 | 0.85 | CRBN (0.69) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL3913660 | 0.84 | CRBN (0.79) | CRBNDDB1NPC1MAPK13MAPK12 | |
| Succinimide SCHEMBL20786978 | 0.83 | CRBN (0.58) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL6153012 | 0.83 | CRBN (0.58) | CRBNITGB3ITGB1ITGAVITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791296-B1 | DIESEL ENGINE OILS | CHEVRON ORONITE CO (US) | 2019-06-26 | — | — | EP | disclosed |
| US-8536102-B2 | Gear oil having low copper corrosion properties | CHEVRON ORONITE COMPANY LLC (US) | 2013-09-17 | — | — | US | disclosed |
| US-20130149191-A1 | GEAR OIL HAVING LOW COPPER CORROSION PROPERTIES | CHEVRON ORONITE COMPANY LLC (US) | 2013-06-13 | — | — | US | disclosed |
| US-8389449-B2 | Gear oil having low copper corrosion properties | CHEVRON ORONITE COMPANY LLC (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1471133-B1 | Gear oil having low copper corrosion properties | CHEVRON ORONITE CO (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20110092401-A1 | Gear oil having low copper corrosion properties | BUITRAGO JUAN A | 2011-04-21 | — | — | US | disclosed |
| US-7871965-B2 | Gear oil having low copper corrosion properties | CHEVRON ORONITE COMPANY LLC (US) | 2011-01-18 | — | — | US | disclosed |
| US-20080300155-A1 | GEAR OIL HAVING LOW COPPER CORROSION PROPERTIES | CHEVRON ORONITE COMPANY, LLC | 2008-12-04 | — | — | US | disclosed |
| US-20040214729-A1 | Gear oil composition having improved copper corrosion properties | CHEVRON ORONITE COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
| EP-1471133-A2 | Gear oil having low copper corrosion properties | Chevron Oronite Company LLC (US) | 2004-10-27 | — | — | EP | disclosed |