Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379924 | 0.87 | ALOX5 (0.42) | ALOX5HSD11B1 | |
| SCHEMBL9380123 | 0.85 | ALOX5 (0.39) | ALOX5HSD11B1 | |
| SCHEMBL9085434 | 0.83 | ALOX5 (0.42) | ALOX5HSD11B1 | |
| SCHEMBL9381401 | 0.82 | ALOX5 (0.37) | ALOX5HSD11B1PTGIR | |
| SCHEMBL9385364 | 0.79 | MAPT (0.40) | ALOX5HSD11B1PTGIRRAB9ASIGMAR1 | |
| SCHEMBL18253218 | 0.79 | HSD11B1 (0.48) | ALOX5HSD11B1RAB9AALDH1A1 | |
| SCHEMBL9086298 | 0.79 | ALOX5 (0.40) | ALOX5PTGIR | |
| SCHEMBL9381912 | 0.77 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL9379755 | 0.77 | ALOX5 (0.41) | ALOX5 | |
| SCHEMBL9440364 | 0.76 | ALOX5 (0.38) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409413-B1 | Diaryl ether heterocycles | ICI PLC (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5208259-A | Lipoxygenase enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES (GB) | 1993-05-04 | — | — | US | disclosed |