Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573898 | 0.83 | DRD2 (0.67) | HTR1ADRD2HTR2AADRA1AHRH1 | |
| SCHEMBL7815509 | 0.82 | HTR2A (0.61) | HTR1ADRD2HTR2AADRA1A | |
| SCHEMBL9381448 | 0.81 | HTR1A (0.76) | HTR1ADRD2HTR2ACYP2D6DRD3 | |
| Hydrochloric Acid SCHEMBL9380816 | 0.80 | HTR1A (0.74) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL4307891 | 0.79 | DRD4 (0.46) | DRD2HTR2ASIGMAR1DRD3ADRA1A | |
| SCHEMBL4299920 | 0.78 | HTR2A (0.57) | HTR1ADRD2HTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL4307355 | 0.78 | DRD4 (0.46) | HTR2ASIGMAR1ADRA1A | |
| SCHEMBL4310830 | 0.78 | DRD4 (0.46) | DRD2HTR2ASIGMAR1DRD3ADRA1A | |
| SCHEMBL4438394 | 0.78 | HTR2A (0.56) | HTR1ADRD2HTR2AADRA1A | |
| SCHEMBL3122433 | 0.76 | SLC6A4 (0.70) | HTR1ADRD2SIGMAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625978-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-30 | — | — | EP | disclosed |
| WO-1993016073-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES, AND THEIR USE AS ANTIPSYCHOTICS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-19 | — | — | WO | disclosed |