Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092627 | 0.86 | SIGMAR1 (0.60) | SIGMAR1BCHEKMT2AMEN1LMNA | |
| SCHEMBL8091657 | 0.79 | SIGMAR1 (0.65) | SIGMAR1 | |
| SCHEMBL8100041 | 0.78 | SIGMAR1 (0.62) | SIGMAR1 | |
| SCHEMBL8091786 | 0.75 | SIGMAR1 (0.60) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL8091986 | 0.75 | SIGMAR1 (0.57) | SIGMAR1 | |
| SCHEMBL8100061 | 0.75 | MEN1 (0.53) | SIGMAR1BCHEKMT2AMEN1DRD2 | |
| SCHEMBL9372958 | 0.75 | KMT2A (0.67) | SIGMAR1BCHEKMT2AMEN1LMNA | |
| SCHEMBL8084153 | 0.74 | SIGMAR1 (0.59) | SIGMAR1DRD3 | |
| SCHEMBL8092963 | 0.74 | SIGMAR1 (0.59) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL8099094 | 0.72 | SIGMAR1 (0.57) | SIGMAR1BCHEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |