Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381590 | 0.89 | ALOX5 (0.79) | ALOX5ALOX12PTGS1PTGS2KCNH2 | |
| SCHEMBL9380468 | 0.88 | ALOX5 (0.54) | ALOX5KDM1A | |
| SCHEMBL9380470 | 0.88 | ALOX5 (0.54) | ALOX5KDM1A | |
| SCHEMBL9381737 | 0.87 | ALOX5 (0.80) | ALOX5KDM1AALOX12PTGS1PTGS2 | |
| SCHEMBL9381731 | 0.87 | ALOX5 (0.80) | ALOX5KDM1AALOX12PTGS1PTGS2 | |
| SCHEMBL9379813 | 0.86 | KCNH2 (0.47) | ALOX5KDM1APTGS1PTGS2KCNH2 | |
| SCHEMBL9384463 | 0.85 | HTR2C (0.54) | ALOX5KDM1A | |
| SCHEMBL9385012 | 0.83 | ALOX5 (0.66) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9381066 | 0.83 | ALOX5 (0.52) | ALOX5KCNH2SCN3A | |
| SCHEMBL9380910 | 0.80 | HTR2C (0.51) | ALOX5KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |