Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | HTR2B | P41595 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380470 | 1.00 | ALOX5 (0.54) | ALOX5HTR2CHTR2BHTR2AMAOB | |
| SCHEMBL9380397 | 0.88 | ALOX5 (0.62) | ALOX5KDM1A | |
| SCHEMBL9380158 | 0.85 | HTR2C (0.50) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9380910 | 0.85 | HTR2C (0.51) | ALOX5HTR2CHTR2BHTR2AMAOB | |
| SCHEMBL9381590 | 0.85 | ALOX5 (0.79) | ALOX5HTR2CHTR2BHTR2A | |
| SCHEMBL7959746 | 0.84 | ALOX5 (0.71) | ALOX5HTR2CHTR2BHTR2AMAOB | |
| SCHEMBL7959749 | 0.84 | ALOX5 (0.71) | ALOX5HTR2CHTR2BHTR2AMAOB | |
| SCHEMBL7971315 | 0.84 | ALOX5 (0.71) | ALOX5HTR2CHTR2BHTR2AMAOB | |
| SCHEMBL9379813 | 0.84 | KCNH2 (0.47) | ALOX5MAOBKDM1A | |
| SCHEMBL9384463 | 0.82 | HTR2C (0.54) | ALOX5HTR2CHTR2BHTR2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |