Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380414 | 1.00 | ALOX5 (0.58) | ALOX5HTR2CKDM1AMAOAMAOB | |
| SCHEMBL9381471 | 0.89 | ALOX5 (0.58) | ALOX5HTR2CMAOARAB9ANPC1 | |
| SCHEMBL9381473 | 0.89 | ALOX5 (0.58) | ALOX5HTR2CMAOARAB9ANPC1 | |
| SCHEMBL9386135 | 0.89 | ALOX5 (0.47) | ALOX5HTR2CKDM1AMAOAMAOB | |
| SCHEMBL9386131 | 0.89 | ALOX5 (0.47) | ALOX5HTR2CKDM1AMAOAMAOB | |
| SCHEMBL9809209 | 0.89 | ALOX5 (0.47) | ALOX5HTR2CKDM1AMAOAMAOB | |
| SCHEMBL9387465 | 0.86 | ALOX5 (0.55) | ALOX5HTR2C | |
| SCHEMBL9387460 | 0.86 | ALOX5 (0.55) | ALOX5HTR2C | |
| SCHEMBL9384463 | 0.86 | HTR2C (0.54) | ALOX5HTR2CKDM1AMAOAMAOB | |
| SCHEMBL9380504 | 0.86 | ALOX5 (0.60) | ALOX5HTR2CFFAR1HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |