Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PTAFR | P25105 | 5/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.43 |
| ▸ | GABRD | O14764 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.43 |
| ▸ | GABRE | P78334 | 2/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508484 | 0.87 | ALOX12 (0.60) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL9384372 | 0.85 | GABRA1 (0.57) | ALOX12SMN1; SMN2PTAFRGABRA1GABRA5 | |
| SCHEMBL8668184 | 0.82 | ALOX12 (0.54) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL9673030 | 0.80 | ALOX12 (0.52) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL9673338 | 0.79 | ALOX12 (0.51) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL9674511 | 0.78 | ALOX12 (0.55) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL10544959 | 0.76 | PTAFR (0.48) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 | |
| SCHEMBL10542901 | 0.76 | PTAFR (0.52) | ALOX12SMN1; SMN2PTAFRCHRM1OPRK1 | |
| SCHEMBL11384670 | 0.76 | ALOX12 (0.77) | ALOX12SMN1; SMN2CHRM1GABRA1GABRA5 | |
| SCHEMBL9673593 | 0.75 | PTAFR (0.61) | ALOX12SMN1; SMN2PTAFRCHRM1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |