Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380777 | 1.00 | ALOX5 (0.76) | ALOX5LMNATDP1FFAR1HTR2A | |
| SCHEMBL9380039 | 0.89 | ALOX5 (0.83) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9380042 | 0.89 | ALOX5 (0.83) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9195122 | 0.87 | ALOX5 (1.00) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9195116 | 0.87 | ALOX5 (1.00) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9387034 | 0.85 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9382596 | 0.85 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9382597 | 0.85 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9387029 | 0.85 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9385667 | 0.84 | ALOX5 (0.56) | ALOX5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |