Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385671 | 1.00 | ALOX5 (0.56) | ALOX5CYP2A6CHRM4FFAR1GPR88 | |
| SCHEMBL9380777 | 0.84 | ALOX5 (0.76) | ALOX5FFAR1 | |
| SCHEMBL9380781 | 0.84 | ALOX5 (0.76) | ALOX5FFAR1 | |
| SCHEMBL9384802 | 0.83 | ALOX5 (0.62) | ALOX5GPR88NAMPT | |
| SCHEMBL9384797 | 0.83 | ALOX5 (0.62) | ALOX5GPR88NAMPT | |
| SCHEMBL7959746 | 0.83 | ALOX5 (0.71) | ALOX5KDM1A | |
| SCHEMBL7959749 | 0.83 | ALOX5 (0.71) | ALOX5KDM1A | |
| SCHEMBL7971315 | 0.83 | ALOX5 (0.71) | ALOX5KDM1A | |
| SCHEMBL9627081 | 0.78 | ALOX5 (0.46) | ALOX5CYP2A6KDM1ACYP3A4CYP2C9 | |
| SCHEMBL9627075 | 0.78 | ALOX5 (0.46) | ALOX5CYP2A6KDM1ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |