Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557441 | 0.86 | PSMB5 (0.52) | PTGS2ALDH1A1KDM4EHPGDHDAC4 | |
| SCHEMBL8505494 | 0.84 | PSMB5 (0.51) | PTGS2ALDH1A1KDM4EHPGDHDAC4 | |
| SCHEMBL642228 | 0.79 | HDAC4 (0.58) | PTGS2ALDH1A1KDM4EHPGDHDAC4 | |
| SCHEMBL3674074 | 0.73 | CA9 (0.50) | ALDH1A1KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL30701949 | 0.73 | CA9 (0.50) | ALDH1A1KDM4EHPGDMAPTSMN1; SMN2 | |
| SCHEMBL27896612 | 0.73 | ALDH1A1 (0.56) | PTGS2ALDH1A1KDM4EHPGDHDAC4 | |
| SCHEMBL8502139 | 0.72 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHDAC4HDAC2 | |
| SCHEMBL28816282 | 0.72 | KDM4E (0.54) | PTGS2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL27996928 | 0.72 | KDM4E (0.54) | PTGS2ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL29068845 | 0.71 | HDAC4 (0.47) | PTGS2ALDH1A1KDM4EHPGDHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0428437-B1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-17 | — | — | EP | disclosed |
| EP-0428437-A1 | 1,2-Benzisoxazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-05-22 | — | — | EP | disclosed |