Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383692 | 0.82 | EGFR (0.45) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9382020 | 0.81 | EGFR (0.43) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9384694 | 0.81 | EGFR (0.43) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9689388 | 0.80 | ALDH1A1 (0.44) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9382965 | 0.78 | ALDH1A1 (0.42) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9381382 | 0.75 | ALDH1A1 (0.40) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL9381112 | 0.74 | ALDH1A1 (0.43) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL28362428 | 0.68 | ALDH1A1 (0.42) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL21333356 | 0.62 | EGFR (0.51) | EGFRSRCMEN1KMT2AALDH1A1 | |
| SCHEMBL1161411 | 0.61 | EGFR (0.64) | EGFRSRCMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372962-B1 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | claimed |
| EP-0372962-A2 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-06-13 | — | — | EP | claimed |
| EP-0372962-B1 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| US-5079246-A | Antidepressants, anxiolytic agents | BEACHAM GROUP P. L. C. (GB) | 1992-01-07 | — | — | US | disclosed |
| EP-0372962-A2 | Quinindolinone derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-06-13 | — | — | EP | disclosed |