Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.81 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380960 | 1.00 | ALOX5 (0.81) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9385549 | 0.92 | ALOX5 (0.83) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9385544 | 0.92 | ALOX5 (0.83) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9195122 | 0.90 | ALOX5 (1.00) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9195116 | 0.90 | ALOX5 (1.00) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL7970862 | 0.89 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7970860 | 0.89 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9382597 | 0.88 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9387034 | 0.88 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL9382596 | 0.88 | ALOX5 (0.98) | ALOX5HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |