Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.66 |
| ▸ | HTR2A | P28223 | 8/20 | 0.57 |
| ▸ | HTR2C | P28335 | 8/20 | 0.57 |
| ▸ | HTR2B | P41595 | 8/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970862 | 1.00 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9380962 | 0.89 | ALOX5 (0.81) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL9380960 | 0.89 | ALOX5 (0.81) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7973024 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7973022 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7969491 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7969487 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7969393 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BGPR88 | |
| SCHEMBL7969398 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BGPR88 | |
| SCHEMBL9385549 | 0.83 | ALOX5 (0.83) | ALOX5HTR2AHTR2CHTR2BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |