Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP4 | P49662 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571282 | 0.83 | HTR2C (0.48) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11101187 | 0.83 | KMT2A (0.46) | HTR2CHRH4HTR2AKMT2A | |
| SCHEMBL11106652 | 0.82 | HRH1 (0.51) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11104195 | 0.82 | HRH1 (0.51) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11102793 | 0.80 | HTR2A (0.47) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11101128 | 0.78 | HTR2C (0.49) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11102472 | 0.78 | HTR2C (0.49) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL8563117 | 0.77 | HRH4 (0.42) | HTR2CHRH1HRH4HTR2A | |
| SCHEMBL11280239 | 0.76 | HTR2C (0.64) | HTR2CHRH1USP2SMN1; SMN2TDP1 | |
| SCHEMBL11292336 | 0.76 | HTR2C (0.60) | HTR2CHRH1USP2SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435566-A | HYPOGLYCEMIA, ANTIHISTAMINE, ANTIDIABETIC ACTIVITY | MARUKO SEIYAKU CO., LTD. (JP) | 1984-03-06 | — | — | US | claimed |
| EP-0276057-B1 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO INC (US) | 1994-03-09 | — | — | EP | disclosed |
| US-4435566-A | HYPOGLYCEMIA, ANTIHISTAMINE, ANTIDIABETIC ACTIVITY | MARUKO SEIYAKU CO., LTD. (JP) | 1984-03-06 | — | — | US | disclosed |