Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.72 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804611 | 0.84 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL8805326 | 0.80 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9684171 | 0.78 | BACE1 (0.48) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9383374 | 0.76 | AKR1B1 (0.81) | AKR1B1 | |
| Minalrestat SCHEMBL30602643 | 0.74 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL9388567 | 0.74 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL49649 | 0.74 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL29727574 | 0.74 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| Minalrestat SCHEMBL9384195 | 0.74 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL9384248 | 0.73 | AKR1B1 (0.82) | AKR1B1AKR1B10AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | claimed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | claimed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | claimed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |