Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383374 | 0.89 | AKR1B1 (0.81) | AKR1B1PTGDR2 | |
| SCHEMBL9383306 | 0.84 | AKR1B1 (0.72) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL8805326 | 0.80 | AKR1B1 (0.67) | AKR1B1 | |
| SCHEMBL9686258 | 0.78 | AKR1B1 (0.64) | AKR1B1AKR1A1PTGDR2 | |
| SCHEMBL10401578 | 0.77 | AKR1B1 (0.62) | AKR1B1AKR1A1 | |
| SCHEMBL9384248 | 0.73 | AKR1B1 (0.82) | AKR1B1AKR1B10AKR1A1 | |
| SCHEMBL2483457 | 0.72 | AKR1B1 (0.56) | AKR1B1 | |
| SCHEMBL9672186 | 0.72 | AKR1B1 (0.56) | AKR1B1AKR1A1 | |
| SCHEMBL10930896 | 0.72 | AKR1B1 (0.56) | AKR1B1AKR1A1 | |
| SCHEMBL10345954 | 0.71 | AKR1B1 (0.55) | AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | claimed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | claimed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | claimed |
| EP-0519600-B1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PROD (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0519600-A1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5169948-A | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| US-5106978-A | Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |