Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 14/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415020 | 1.00 | UTS2R (0.62) | UTS2RMAPK1HRH2HRH1SCN9A | |
| SCHEMBL7402928 | 1.00 | UTS2R (0.62) | UTS2RMAPK1HRH2HRH1SCN9A | |
| SCHEMBL7407107 | 0.95 | UTS2R (0.61) | UTS2RMAPK1HRH2HRH1DRD2 | |
| SCHEMBL7403794 | 0.94 | UTS2R (0.55) | UTS2RMAPK1 | |
| SCHEMBL7408984 | 0.93 | UTS2R (0.65) | UTS2RHRH2HRH1 | |
| SCHEMBL7409507 | 0.92 | HRH2 (0.55) | UTS2RMAPK1HRH2HRH1SCN9A | |
| SCHEMBL7404900 | 0.91 | UTS2R (0.56) | UTS2RHRH2HRH1SCN9A | |
| SCHEMBL7411617 | 0.88 | UTS2R (0.56) | UTS2RHRH2HRH1 | |
| SCHEMBL9384147 | 0.88 | HRH2 (0.61) | HRH2HRH1DRD2DRD4 | |
| SCHEMBL7568066 | 0.88 | HRH2 (0.61) | HRH2HRH1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369077-B1 | OSTEOPOROSIS, PERIODONTITIS, AND ARTHRITIS | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |
| EP-0991753-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0991753-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998050534-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |