Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9388117 | 0.91 | ALDH1A1 (0.40) | CA12CA9ALDH1A1MEN1KMT2A | |
| SCHEMBL9383572 | 0.89 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9385854 | 0.89 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9387237 | 0.87 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL9383419 | 0.85 | PGR (0.39) | ALDH1A1MEN1KMT2APGRMAPT | |
| SCHEMBL9388468 | 0.81 | TDP1 (0.44) | CA12CA9ALDH1A1KMT2ATSHR | |
| SCHEMBL9384030 | 0.80 | TP53 (0.39) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL8319660 | 0.79 | AKR1B1 (0.54) | MEN1KMT2AAKR1B1 | |
| SCHEMBL31186345 | 0.79 | MEN1 (0.44) | ALDH1A1MEN1KMT2APGRMAPT | |
| SCHEMBL9384412 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |