Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389470 | 0.87 | MAPT (0.43) | MAPK1DRD2DRD1F3GAA | |
| SCHEMBL9205461 | 0.76 | MAPK1 (0.41) | MAPK1DRD2DRD1GAAKDM4E | |
| SCHEMBL50939 | 0.70 | HTR1A (0.43) | MAPK1DRD2DRD1F3MAPT | |
| SCHEMBL50569 | 0.70 | HTR1A (0.43) | MAPK1DRD2DRD1F3MAPT | |
| SCHEMBL23036790 | 0.70 | EGLN1 (0.44) | DRD2DRD1EGLN1GRIA2GAA | |
| SCHEMBL31369369 | 0.69 | EGLN1 (0.43) | EGLN1GRIA2GAAMAPT | |
| SCHEMBL8964041 | 0.68 | GRIA2 (0.39) | DRD2DRD1EGLN1F3GRIA2 | |
| SCHEMBL8964416 | 0.68 | GRIA2 (0.39) | DRD2DRD1EGLN1F3GRIA2 | |
| SCHEMBL9548214 | 0.67 | GAA (0.46) | DRD2EGLN1GRIA2GAAMAPT | |
| SCHEMBL9543916 | 0.67 | ANPEP (0.44) | MAPK1EGLN1GRIA2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994003432-A1 | POLYHYDROXYLATED NAPHTHYL 2-CARBOXYLATE, AND QUINOLYL AND ISOQUINOLYL 3-CARBOXYLATE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-02-17 | — | — | WO | disclosed |