Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386696 | 0.84 | MTNR1A (0.36) | CYP26A1MAPTCYP19A1SIGMAR1HTR1A | |
| SCHEMBL1991216 | 0.79 | GBA1 (0.33) | MAPTCYP19A1SIGMAR1HTR1A | |
| SCHEMBL8318762 | 0.79 | GBA1 (0.33) | MAPTCYP19A1SIGMAR1HTR1A | |
| SCHEMBL8324468 | 0.79 | GBA1 (0.33) | MAPTCYP19A1SIGMAR1HTR1A | |
| SCHEMBL4623036 | 0.73 | CYP26A1 (0.67) | CYP26A1CYP19A1SIGMAR1HTR1ADRD2 | |
| SCHEMBL9630417 | 0.73 | CYP19A1 (0.63) | CYP26A1CYP19A1SIGMAR1HTR1ADRD2 | |
| SCHEMBL7288575 | 0.73 | CYP26A1 (0.67) | CYP26A1CYP19A1SIGMAR1HTR1ADRD2 | |
| Trifluoromethanesulfonic Acid SCHEMBL9419763 | 0.67 | CYP26A1 (0.55) | CYP26A1CYP19A1SIGMAR1DRD2DRD3 | |
| SCHEMBL6015851 | 0.66 | HTT (0.38) | MAPTMCHR1OPRK1 | |
| SCHEMBL8319230 | 0.66 | HTT (0.38) | MAPTMCHR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |