Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931684 | 0.91 | DGAT1 (0.60) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL7886309 | 0.89 | DGAT1 (0.74) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL13218506 | 0.89 | DGAT1 (0.66) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL8931127 | 0.88 | DGAT1 (0.72) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL7883247 | 0.87 | DGAT1 (0.71) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL8931748 | 0.85 | DGAT1 (0.71) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL9282291 | 0.85 | DGAT1 (0.62) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL8756019 | 0.85 | DGAT1 (0.69) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL8931733 | 0.85 | DGAT1 (0.62) | DGAT1MAPTGAALMNAKDM4E | |
| SCHEMBL8755567 | 0.85 | DGAT1 (0.69) | DGAT1MAPTGAALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331232-B1 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |