Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGFR | P43088 | 16/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | FES | P07332 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.34 |
| ▸ | FER | P16591 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327565 | 0.85 | KMT2A (0.41) | PTGFRMKNK2MEN1KMT2A | |
| SCHEMBL1780572 | 0.74 | DYRK1B (0.52) | MTNR1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL8331450 | 0.73 | KMT2A (0.44) | MKNK2MEN1KMT2A | |
| SCHEMBL8328480 | 0.68 | MEN1 (0.42) | CYP3A4KDRMEN1KMT2APTGES | |
| SCHEMBL8327249 | 0.68 | GSK3B (0.42) | MEN1KMT2A | |
| SCHEMBL8326687 | 0.64 | SRC (0.46) | KDRMEN1KMT2A | |
| SCHEMBL6249745 | 0.63 | DYRK1B (0.50) | MTNR1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL6246112 | 0.62 | DYRK1B (0.56) | PLK4AURKAJAK2ROCK2PRKD3 | |
| SCHEMBL8327343 | 0.62 | ALDH1A1 (0.46) | — | |
| SCHEMBL6247571 | 0.62 | DYRK1A (0.49) | MTNR1APLK4AURKAJAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |