Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | PLAA | Q9Y263 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PTGFR | P43088 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331450 | 0.87 | KMT2A (0.44) | KMT2AMEN1MAPTHTTMGAM | |
| SCHEMBL9387149 | 0.85 | PTGFR (0.38) | KMT2AMEN1MKNK2PTGFR | |
| SCHEMBL8328480 | 0.81 | MEN1 (0.42) | KMT2AMEN1MGAMAMY1AGAA | |
| SCHEMBL8327249 | 0.81 | GSK3B (0.42) | KMT2AMEN1MAPTHTTMGAM | |
| SCHEMBL8326687 | 0.75 | SRC (0.46) | KMT2AMEN1MAPTMGAMAMY1A | |
| SCHEMBL8330358 | 0.72 | KMT2A (0.41) | KMT2AMEN1MAPTHTTMGAM | |
| SCHEMBL8322914 | 0.72 | NPC1 (0.46) | MAPTMGAMAMY1AGAASI | |
| SCHEMBL8327343 | 0.71 | ALDH1A1 (0.46) | MAPTHPGD | |
| SCHEMBL8325943 | 0.71 | KMT2A (0.42) | KMT2AMEN1MAPTHTTMGAM | |
| SCHEMBL12391289 | 0.70 | GPR35 (0.46) | KMT2AMEN1MAPTMGAMAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |