Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.48 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776278 | 0.95 | RIPK1 (0.65) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| Toluene SCHEMBL28245885 | 0.93 | TRPC3 (0.56) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL28142751 | 0.91 | RIPK1 (0.55) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| SCHEMBL12944008 | 0.88 | RIPK1 (0.63) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| Trifluoroacetic Acid SCHEMBL18050102 | 0.86 | RIPK1 (0.59) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| SCHEMBL27574946 | 0.86 | RIPK1 (0.62) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| SCHEMBL216202 | 0.86 | RIPK1 (0.62) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| SCHEMBL4019469 | 0.86 | RIPK1 (0.62) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| SCHEMBL27574934 | 0.86 | RIPK1 (0.62) | RIPK1HSD11B1PARP14PARP10HSP90AA1 | |
| Water SCHEMBL27700791 | 0.85 | RIPK1 (0.60) | RIPK1HSD11B1PARP14PARP10HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105111210-B | Condensed imidazole derivatives as IDO inhibitor | 新联基因公司 | 2018-10-09 | — | — | CN | claimed |
| CN-107624110-A | Inhibitor of lysyloxidase sample 2 and application thereof | 法玛克亚公司 | 2018-01-23 | — | — | CN | claimed |
| CN-107592861-A | It is fluorinated inhibitor of lysyloxidase sample 2 and application thereof | 法玛克亚公司 | 2018-01-16 | — | — | CN | claimed |
| CN-103547579-B | Fused imidazole derivatives as IDO inhibitors | 新联基因公司 | 2017-02-15 | — | — | CN | claimed |
| EP-2635281-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | University Of Hawaii (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061505-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIVERSITY OF HAWAII (US) | 2012-05-10 | — | — | WO | claimed |
| CN-110139861-A | Pyran derivatives as inhibitors of CYP11A1 (cytochrome P450 monooxygenase 11A1) | 奥赖恩公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-107001271-B | Hydroxyamidine derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-106715440-B | Imidazo isoindoles derivative, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2019-02-22 | — | — | CN | disclosed |
| CN-109348715-A | pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2019-02-15 | — | — | CN | disclosed |
| CN-108137518-A | As 6 inhibitor of histone deacetylase 1,3,4- oxadiazole derivatives compound and include its pharmaceutical composition | 株式会社钟根堂 | 2018-06-08 | — | — | CN | disclosed |
| EP-3122746-B1 | PHENYLPIPERIDINECARBOXAMIDE DERIVATIVES AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2018-04-25 | — | — | EP | disclosed |
| CN-104755083-B | Urea and amide derivatives of aminoalkyl piperazine and application thereof | 南方研究所 | 2018-04-10 | — | — | CN | disclosed |
| WO-2006028545-A2 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006021655-A2 | OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2006-03-02 | — | — | WO | disclosed |
| WO-2006021656-A2 | AMINOPIPERIDINE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONISTS | SANOFI-AVENTIS (FR) | 2006-03-02 | — | — | WO | disclosed |
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |
| CN-1137886-C | 2,3-dioxo-1,2,3,4-tetrahydro-quinoyxalinyl derivatives | ��˹��ŵ�� | 2004-02-11 | — | — | CN | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |