Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27574946 | 0.89 | RIPK1 (0.62) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL216202 | 0.89 | RIPK1 (0.62) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL27574934 | 0.89 | RIPK1 (0.62) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| Water SCHEMBL27700791 | 0.88 | RIPK1 (0.60) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL24365000 | 0.86 | RIPK1 (0.63) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL938757 | 0.86 | RIPK1 (0.59) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL19917196 | 0.86 | HSD11B1 (0.59) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL9336982 | 0.86 | RIPK1 (0.63) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL28112744 | 0.85 | RIPK1 (0.57) | RIPK1HSD11B1HSP90AA1HSP90AB1PRMT5 | |
| SCHEMBL8596155 | 0.85 | PARP14 (0.62) | RIPK1HSD11B1HSP90AA1HSP90AB1SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102686566-A | Novel tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA | 2012-09-19 | — | — | CN | claimed |
| CN-102686566-A | Novel tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA | 2012-09-19 | — | — | CN | disclosed |
| US-7572814-B2 | 3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds | CYTOKINETICS, INCORPORATED (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070161674-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161674-A1 | Certain chemical entities, compositions, and methods | TP53, VHL, RB1 | RIPK1 4239/4885HSD11B1 1683/4885HSP90AA1 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.