Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20429944 | 0.83 | NOS1 (0.38) | ALDH1A1CYP3A4TDP1NOS3NOS2 | |
| SCHEMBL30611996 | 0.79 | CYP3A4 (0.36) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL16244697 | 0.79 | CYP3A4 (0.36) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL30943973 | 0.78 | CYP3A4 (0.35) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL12303081 | 0.77 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL29512854 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL5844082 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL1279214 | 0.72 | KDM4E (0.54) | KDM4EALDH1A1HPGDMAPTCYP3A4 | |
| SCHEMBL13779517 | 0.70 | HTT (0.51) | KDM4EALDH1A1HPGDMAPTCYP2C19 | |
| SCHEMBL1744864 | 0.70 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389189-B1 | Diazepine antiallergy agents | PFIZER LTD (GB) | 1994-05-18 | — | — | EP | disclosed |
| US-5008263-A | Platelet activating factor antagonists; antiallergens; antiinflammatory agents | PFIZER INC. (US) | 1991-04-16 | — | — | US | disclosed |
| CN-1045783-A | Diaza class anti-allergy medicament | PFIZER (US) | 1990-10-03 | — | — | CN | disclosed |
| EP-0389189-A2 | Diazepine antiallergy agents | Pfizer Limited (GB) | 1990-09-26 | — | — | EP | disclosed |