Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9385657 | 0.99 | MAPT (0.44) | HTR1AADRA1BHTR2AMAPTADRA1A | |
| SCHEMBL9386908 | 0.96 | HTR1A (0.45) | HTR1AADRA1BHTR2AMAPTADRA1A | |
| Hydrochloric Acid SCHEMBL9384753 | 0.95 | MAPT (0.44) | HTR1AADRA1BHTR2AMAPTADRA1A | |
| SCHEMBL9388387 | 0.88 | HTR1A (0.46) | HTR1AHTR2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL9383653 | 0.88 | MAPT (0.48) | HTR1AADRA1BHTR2AMAPTSMN1; SMN2 | |
| SCHEMBL9384567 | 0.88 | HTR1A (0.45) | HTR1AHTR2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9385200 | 0.88 | HTR1A (0.45) | HTR1AHTR2AMAPTSMN1; SMN2HRH1 | |
| SCHEMBL9385901 | 0.88 | HTR1A (0.42) | HTR1AHTR2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL9384552 | 0.88 | HTR1A (0.42) | HTR1AHTR2AMAPTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL9385389 | 0.87 | HTR1A (0.46) | HTR1AHTR2AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |