Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384119 | 0.97 | HTR1A (0.45) | ALDH1A1KDM4ETDP1MAPTGAA | |
| Oxalic Acid SCHEMBL9387022 | 0.96 | HTR1A (0.48) | ALDH1A1KDM4ETDP1MAPTHTR1A | |
| SCHEMBL9388964 | 0.93 | HTR1A (0.50) | ALDH1A1KDM4EMAPTHTR1AHTR2A | |
| SCHEMBL9387918 | 0.92 | HTR1A (0.51) | ALDH1A1KDM4ETDP1HTR1AHTR2A | |
| Oxalic Acid SCHEMBL9388553 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1MAPTHTR1A | |
| Oxalic Acid SCHEMBL9388560 | 0.89 | ALDH1A1 (0.46) | ALDH1A1KDM4ETDP1MAPTHTR1A | |
| SCHEMBL9386487 | 0.88 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1MAPTGAA | |
| SCHEMBL9384577 | 0.87 | HTR1A (0.46) | ALDH1A1KDM4EMAPTHTR1AHTR2A | |
| Oxalic Acid SCHEMBL9386065 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4ETDP1MAPTGAA | |
| Oxalic Acid SCHEMBL9386061 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4ETDP1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |