Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9388391 | 1.00 | GABRA1 (0.33) | GABRA1GABRB1CYP1A2CYP2D6 | |
| SCHEMBL23363293 | 0.80 | GABRA1 (0.39) | GABRA1GABRB1 | |
| SCHEMBL29757434 | 0.80 | GABRA1 (0.39) | GABRA1GABRB1 | |
| SCHEMBL23489958 | 0.80 | GABRA1 (0.39) | GABRA1GABRB1 | |
| SCHEMBL9381640 | 0.77 | — | — | |
| SCHEMBL12356952 | 0.75 | GABRA1 (0.46) | GABRA1GABRB1 | |
| SCHEMBL14612311 | 0.73 | TSHR (0.34) | GABRA1GABRB1 | |
| SCHEMBL9381645 | 0.72 | — | — | |
| SCHEMBL9258876 | 0.69 | LMNA (0.32) | — | |
| SCHEMBL29873099 | 0.68 | HTT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5336771-A | Certain 3,4-dihydro-2H-pyrano[2,3-b]pyridines | PFIZER INC. (US) | 1994-08-09 | — | — | US | disclosed |
| EP-0445950-B1 | Novel pyridine derivatives and processes for their synthesis | PFIZER (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5068333-A | 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration | PFIZER INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0445950-A1 | Novel pyridine derivatives and processes for their synthesis | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |