Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 13/20 | 0.69 |
| ▸ | CA2 | P00918 | 13/20 | 0.69 |
| ▸ | CA4 | P22748 | 8/20 | 0.61 |
| ▸ | CA9 | Q16790 | 8/20 | 0.61 |
| ▸ | CA12 | O43570 | 4/20 | 0.55 |
| ▸ | CA3 | P07451 | 4/20 | 0.55 |
| ▸ | CA6 | P23280 | 4/20 | 0.55 |
| ▸ | CA5A | P35218 | 4/20 | 0.55 |
| ▸ | CA7 | P43166 | 4/20 | 0.55 |
| ▸ | CA13 | Q8N1Q1 | 4/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CA11 | O75493 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13454384 | 0.82 | CA2 (1.00) | CA1CA2CA4CA9CA12 | |
| SCHEMBL11049891 | 0.77 | CA1 (1.00) | CA1CA2CA4CA9CA12 | |
| SCHEMBL9403512 | 0.76 | CA1 (0.80) | CA1CA2CA4CA9CA12 | |
| SCHEMBL19383010 | 0.76 | CA1 (0.80) | CA1CA2CA4CA9CA12 | |
| SCHEMBL19382585 | 0.75 | CA1 (0.74) | CA1CA2CA4CA9CA12 | |
| Bromide SCHEMBL9403550 | 0.74 | CA1 (0.78) | CA1CA2CA4CA9CA12 | |
| Propazolamide SCHEMBL1817525 | 0.74 | CA1 (1.00) | CA1CA2CA4CA9CA12 | |
| SCHEMBL19382598 | 0.73 | CA1 (0.70) | CA1CA2CA4CA9CA12 | |
| SCHEMBL9674316 | 0.72 | CA1 (0.74) | CA1CA2CA4CA9CA12 | |
| Acetazolamide SCHEMBL23219 | 0.72 | CA1 (1.00) | CA1CA2CA4CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594602-A1 | TOPICALLY ACTIVE OCULAR THIADIAZOLE SULFONAMIDE CARBONIC ANHYDRASE INHIBITORS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0594602-A4 | TOPICALLY ACTIVE OCULAR THIADIAZOLE SULFONAMIDE CARBONIC ANHYDRASE INHIBITORS. | RES CORP TECHNOLOGIES INC (US) | 1993-06-16 | — | — | EP | disclosed |