Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DDO | Q99489 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389943 | 0.84 | DAO (0.42) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9390047 | 0.84 | DAO (0.42) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9389978 | 0.80 | DAO (0.41) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9392688 | 0.80 | DAO (0.41) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9388974 | 0.79 | DAO (0.49) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9392228 | 0.76 | DAO (0.43) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9390076 | 0.76 | DAO (0.43) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9389400 | 0.75 | DAO (0.49) | DAOKDM4EPKMALDH1A1HPGD | |
| SCHEMBL9389927 | 0.75 | DAO (0.49) | DAOKDM4EPKMDDOPDE2A | |
| SCHEMBL9389013 | 0.73 | DAO (0.58) | DAODDO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994007500-A1 | 2,5-DIHYDRO-2,5-DIOXO-1H-AZEPINES AND 2,5-DIHYDRO-2-OXO-1H-AZEPINES AND THE USE THEREOF AS EXCITATORY AMINO ACID AND GLYCINE RECEPTOR ANTAGONISTS | WEBER ECKARD (US) | 1994-04-14 | — | — | WO | disclosed |