Vintriptol

Vintriptol

SCHEMBL93959

CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@]1(O)[C@H](O)[C@]2(CC)C=CCN3CC[C@@]4(c5cc([C@@]6(C(=O)OC)C[C@@H]7C[N@](CCc8c6[nH]c6ccccc86)C[C@](O)(CC)C7)c(OC)cc5N(C)[C@@H]14)[C@@H]32

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 15/20 1.00
TUBB P07437 15/20 1.00
TUBA3C P0DPH7 15/20 1.00
TUBA1B P68363 15/20 1.00
TUBA4A P68366 15/20 1.00
TUBB4B P68371 15/20 1.00
TUBB3 Q13509 15/20 1.00
TUBB2A Q13885 15/20 1.00
TUBB8 Q3ZCM7 15/20 1.00
TUBA3E Q6PEY2 15/20 1.00
TUBA1A Q71U36 15/20 1.00
TUBA1C Q9BQE3 15/20 1.00
TUBB6 Q9BUF5 15/20 1.00
TUBB2B Q9BVA1 15/20 1.00
TUBB1 Q9H4B7 15/20 1.00
MLNR O43193 1/20 0.79
PTGS2 P35354 1/20 0.79
KCNH2 Q12809 1/20 0.79
GHSR Q92847 1/20 0.79
CYP3A4 P08684 3/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18602043 0.90 MLNR (0.91) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL18602221 0.90 MLNR (0.91) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Desacetylvinblastinehydrazide SCHEMBL29410063 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Desacetylvinblastinehydrazide SCHEMBL17529277 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Desacetylvinblastinehydrazide SCHEMBL29376353 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL19787808 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL18602222 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL19443227 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL13011060 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
Desacetylvinblastinehydrazide SCHEMBL15507828 0.89 MLNR (0.90) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
CN-104244968-A PH20 polypeptide variants, formulations, and uses thereof HALOZYME INC 2014-12-24 CN claimed
JP-2011528275-A 2011-11-17 JP claimed
EP-2313122-A1 DRUG DELIVERY MEDICAL DEVICE Micell Technologies, Inc. (US) 2011-04-27 EP claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
WO-2010009335-A1 DRUG DELIVERY MEDICAL DEVICE MICELL TECHNOLOGIES, INC. (US) 2010-01-21 WO claimed
CN-100500218-C Anti tumour medicinal composition SHANDONG LANJIN BIOLOG ENGINEE (CN) 2009-06-17 CN claimed
CN-101390827-A Sustained-release injection containing methotrexate synergist JINAN SHUAIHUA MEDICINE TECHNO (CN) 2009-03-25 CN claimed
US-20090054369-A1 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS RND PHARMACEUTICALS, INC. (US) 2009-02-26 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
CN-1846670-A Anticancer implant JINAN SHUAIHUA MEDICINE SCI TE (CN) 2006-10-18 CN claimed
CN-1839817-A Anticancer sustained-release injection containing taxane JINAN SHUAIHUA MEDICINE TECHNO (CN) 2006-10-04 CN claimed
CN-1824314-A Slow-release agent containing hormone anticancer medicine JINAN KANGQUAN MEDICINE SCI & (CN) 2006-08-30 CN claimed
CN-1733302-A Anticancer implantation agent KONG QINGZHONG (CN) 2006-02-15 CN claimed
CN-1686544-A Anti entity tumour medicinal composition containing plant alkaloid SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN claimed
CN-1686553-A Anti entity tumour medicinal composition SHANDONG LANJIN BIOLOG ENGINEE (CN) 2005-10-26 CN claimed
CN-1679949-A Anticarcinogenic internal implant agent LANJIN BIOLOG ENGINEERING CO L (CN) 2005-10-12 CN claimed
CN-1676165-A In vivo slow-releasing anticancer medicinal composition LANJIN BIOENGINEERING CO LTD S (CN) 2005-10-05 CN claimed
EP-0393575-B1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent SEARLE & CO (US) 1994-03-16 EP claimed
EP-0393575-A1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent G.D. Searle & Co. (US) 1990-10-24 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090054369-A1 PHARMACEUTICAL COMPOSITIONS OF SILICON-CONTAINING SUBSTITUTED ADENOSINE NUCLEOSIDE AMIDE ANALOGS SI, SLC29A2, SLC29A1 TUBB4A 4057/4885TUBB 4051/4885TUBA3C 4574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.